Exchange Mail Routing Issue '451 5.7.3 Cannot achieve Exchange Server authentication'
Thanks to: http://www.petenetlive.com/ Problem While putting in a New Exchange 2010 server today, I test moved a mailbox to this new site, and could not get mail to flow to the Exchange 2010 server at the clients main site. 451 4.4.0 Primary target IP address responded with: "451 5.7.3 Cannot achieve Exchange Server authentication." Attempted failover to alternate host , but that did not succeed. Either there are no alternative hosts, or delivery failed to all alternative hosts. Mail flowed from the main site to this new site, and internal mail at the new site was fine, but any mail destined for the main site, or going external (because the main site has the only server that can use the Exchange organization send connector) would fail with this error. Solution I did a lot of trawling to try and find the answer to this, and discovered lots of reasons for this to happen, so rather than just posting what fixed mine, from the most popular to the most obscure try ...